Nationality Date of Birth Address for Communication Tel Fax Email

Indian 11 April 1973 Dr. K.Pandima Devi Assistant Professor Department of Biotechnology Alagappa University Karaikudi 630 003 Tamil Nadu Tel: 04565-225215 (Off) + 91 4565 225215 + 91 4565 225202 devikasi@yahoo.com

Educational Qualification

# Title of dissertation : Serum Glycoproteins in Pulmonary Tuberculosis

* Title of thesis : Hepatoprotective effects of Premna tomentosa Linn (Verbanacae) against acetaminophen/paracetamol induced acute hepatitis in rats

Details of Employment (Past & Present)

May 2003- Till date

Lecturer in Department of Biotechnology, Alagappa University , Karaikudi, Tamil Nadu

March 2002- March 2003

Postdoctoral trainee, Department of Peptide Chemistry, CSIC, Barcelona , Spain

Feb 2001- Sep 2001

Worked as Project associate in National Institute of Immunology, New Delhi, India in the project “ Isolation and characterization of genes encoding sperm surface antigens by screening human testis expression cDNA Lib: Identification of a candidate molecule(s) for development of contraceptive vaccine”

Sep 1995 to April 1996

Lecturer in Department of Biochemistry, S.Chattanatha Karayalar College of Arts and Sciences, Tenkasi, INDIA

Details of professional training and research experience

April 2002- March 2003: CID-CSIC, Barcelona, SPAIN. Synthesis of citrulinated peptides by F-moc chemistry and diagnosing arthritis by ELISA

March 2000- April 2000: Defense Institute of Physiology and Allied Sciences, New DelhiEvaluation of the herbal drugs P.tomentosa to antioxidant and immunomodulation properties, studies on apoptosis and DNA fragmentation in splenocytes and macrophages

Feb 2000: Department of Anatomy (Electron Microscopy Facility), All India Institute of Medical Sciences (AIIMS), New Delhi Training course in Electron Microscopy

Aug 1994 to Sep 1994:Pasteur Institute of India, CoonoorTraining course in observing the various procedures of production and quality control of Rabies vaccine and DTP group of vaccines

List of publications

2009

Study of p53 codon 72 polymorphism and codon 249 mutations in Southern India in relation to age, alcohol drinking and smoking habits (Human and Experimental Toxicology, U.K Sage Publications, Ltd) (In Press) [IF-1.456]

Neuroprotective effect of Seaweeds inhabiting South Indian coastal area (Hare Island, Gulf of Mannar Marine Biosphere Reserve): Cholinesterase Inhibitory effect of Hypnea valentine and Ulva reticulate. N. Suganthy, S. Karutha Pandian, K. Pandima Devi. Neuroscience Letters, 468 (2010) 216–219 (Elsevier) [IF-2.2]

Mangrove Plants Extract: Radical Scavenging Activities and Its Battle against Food Borne Pathogens. N. Suganthy, P. Kesika, S. Karutha Pandian, K. Pandima Devi. Research in Complementary Medicine, 2009, 16, 41-48 [Karger Press][IF-1.185]

Cholinesterase inhibitors from Sargassum and Gracilaria grassa: Seaweeds inhabiting South Indian coastal area ( Hare Island , Gulf of Mannar ). N. Suganthy, S. Karutha Pandian, K. Pandima Devi. Natural Product Research, 2009, 23, 355-369. [Taylor and Francis , UK ] [IF-0.798]

2008

Cholinesterase inhibitory effects of Rhizophora lamarckii, Avicennia officinalis, Sesuvium portulacastrum and Suevada monica: Mangroves inhabiting Indian coastal area (Vellar Estuary). N Suganthy , S Karutha Pandian, K Pandima Devi. Journal of Enzyme Inhibition and Medicinal Chemistry, 2008, 1-6 [Taylor and Francis] [IF-1.636]

Bioprotective properties of seaweeds: In vitro evaluation of antioxidant activity and antimicrobial activity against food borne bacteria in relation to polyphenolic content . K Pandima Devi , N Suganthy , P Kesika , S Karutha Pandian. BMC Complementary and Alternative Medicine, 2008, 8:38 [Biomed Central Ltd, UK ] [IF-2.12]

Olive oil protects rat liver microsomes against benzo(a)pyrene induced oxidative damages- an in vitro study. K. Pandima Devi, P.V. Kiruthiga, S. Karutha Pandian, G. Archunan and S. Arun. Molecular Nutrition and Food Research, 2008, 52, S95-102 [ Wiley-VCH Verlag] [IF-3.308]

2007

P.V. Kiruthiga, R. Beema Shafreen, S. Karutha Pandian, K. Pandima Devi. 2007 Silymarin protection against major reactive oxygen species released by environmental toxins: -Exogenous H 2O 2 exposure in erythrocytes. Basic and Clinical Pharmacology and Toxicology, 100, 414-419[Blackwell Publishers] [IF-2.073]

P.V. Kiruthiga, R. Beema Shafreen, S. Karutha Pandian, S. Arun, S.Govindu, K. Pandima Devi. 2007. Protective effect of silymarin on erythrocyte haemolysate against benzo(a)pyrene and exogenous reactive oxygen species (H 2O 2) induced oxidative stress. Chemosphere, 68,1511-1518[Elsevier] [IF-3.054]

2006

Maria L. Perez, Maria J. Gomara, Devi Kasi, Ana Alonso, Odette Vinas, Guadalupe Ercilla, Raimon Sanmarti, Isabel Haro. 2006. Synthesis of overlapping fibrin citrullinated peptides and their use for diagnosing rheumatoid arthritis. Chemical Biology and Drug Design, 68, 194-200. [Blackwell Publishers] [IF-2.375]

2005

K. Pandima Devi, S. Karutha Pandian and N.S. Senthil Kumar. 2005. Cholinestrase activity in clam Meretrix casta: Possible biomarker for organophosphate pesticide pollution. Bulletin of Environmental Contamination and Toxicology. Feb;74(2):250-5 [Springer-Verlag publishers, USA ] [IF-0.582]

K. Pandima Devi , M. Sreepriya, K. Balakrishna, T. Devaki. 2005. Protective effect of Premna tomentosa extract (L. Verbanacae) on acetaminophen induced mitochondrial dysfunction in rats. Molecular and Cellular Biochemistry, Vol 272, No 1-2 [ Springer Science Business Media B.V , The Netherlands ] [IF-1.862]

2004

K. Pandima Devi , M. Sreepriya, K. Balakrishna, T. Devaki. Protective effect of Premna tomentosa (L.Verbenaceae) extract on membrane bound phosphatases and inorganic cations transport in acetaminophen induced hepatotoxicity rats. J Ethnopharmacol. 2004 Aug;93(2-3):371-5. [Elsevier Publishers] [IF-2.260]

Pandima Devi K , Sai Ram M, Sreepriya M, Ilavazhagan G, Devaki T, Selvamurthy W. Immunomodulatory effects of Premna tomentosa (L.Verbanacae) extract in J 779 macrophage cell cultures under Cr (VI) induced immunosuppression. J Altern Complement Med. 2004 Jun;10(3):535-9. [Mary Ann Liebert, Inc., USA ] [IF-1.051]

K.Pandima Devi , M.Sree Priya, K.Balakrishna, G.Veluchamy, T.Devaki. Assessment of the protective potential of Premna tomentosa (L.Verbanacea) extract on lipid profile and lipid metabolizing enzymes in acetaminophen intoxicated rats. J Altern Complement Med.2004 Jun;10(3):540-6. [Mary Ann Liebert, Inc., USA ] [IF-1.051]

1998-2003

 K. Pandima Devi , M. Sreepriya, T. Devaki, K. Balakrishna. Anti-nociceptive and hypnotic effects of Premna tomentosa L.(Verbanacae) in experimental animals. Pharmacology Biochemistry and Behaviour ,75 (2003) 261–264 [Elsevier Publishers] [IF-2.751]

K. Pandima Devi , M.Sai Ram, M.Sree Priya, G.Ilavazhagan, T.Devaki. 2003. Immunomodulatory effects of Premna tomentosa extract against Cr (VI) induced toxicity in splenic lymphocytes - an in vitro study. Biomedicine and Pharmacotherapy, 57(2), 105-108. [Elsevier Publishers] [IF-2.198]

R.Anandan, K.Pandima Devi, T.Devaki, P.Govindaraju. 1999. Protective effects of Picrorhiza kurroa on urea cycle enzymes in D-Galactosamine induced hepatitis in rats. Medical Science Research, 27(2), 127-130. [Chapman & Hall Publishers, UK ] [IF-0.384]

K.Pandima Devi , T.Devaki. 1998. Protective effect of Premna tomentosa on acetaminophen- induced acute hepatitis in rats. Medical Science Research, 26, 785-787. [Chapman & Hall Publishers, UK ] [IF-0.384]

K.Pandima Devi , R.Anandan, K.Balakrishna, T.Devaki. 1998. Effect of Premna tomentosa on rat liver antioxidant defence system in acetaminophen intoxicated rats. Biomedical Research, 19(5), 339-342. [Biomedical Research Foundation , Japan ] [IF-0.412]

R.Anandan, M.Sree Priya, K.Pandima Devi, T.Devaki. 1998. Preventive effects of Picrorhiza kurroa on D-Galactosamine - induced hepatitis in rats. Journal of Clinical Biochemistry and Nutrition, 25, 87-95. [Institute of Applied Biochemistry, Japan ] [IF-0.630]

TOTAL IMPACT FACTOR OF THE PUBLICATIONS- 33.77

REVIEW ARTICLES IN BOOKS

• Liposome Technology and its Applications. K. Pandima Devi , N. Suganthy, PV. Kiruthiga, S. Karutha Pandian. Cellular and Biochemical Science Book (Edited Volume), IK International Publishers, New Delhi , 2009 (In Press)
• Flavonoids from complementary and alternative medicine: Mechanism of imunomodulation of macrophages. K. Pandima Devi, PV. Kiruthiga and S. Karutha Pandian. Book series on Bioactive Natural Products. Studium Press LLC, USA 2009 (In Press)

• Emerging Role of Flavonoids in Inhibition of NF-kB -Mediated Signaling Pathway: A Mini Review. K. Pandima Devi, PV. Kiruthiga, S. Karutha Pandian. For the special Issue of IJBPS (International Journal of Biomedical and Pharmaceutical Sciences) on Ethnomedicinal Phytophores in Disease Management, with Guest Editor, Dr. Debprasad Chattopadhyay, India . Global Science Books Ltd (UK) (In Press)
• Cholinesterase inhibitors from plants: Possible treatment strategy for neurological disorders- A Mini Review. N. Suganthy, S. Karutha Pandian and K. Pandima Devi. For the special Issue of IJBPS (International Journal of Biomedical and Pharmaceutical Sciences) on Ethnomedicinal Phytophores in Disease Management, with Guest Editor, Dr. Debprasad Chattopadhyay, India . Global Science Books Ltd (UK) (In Press) 

• SERC Fast Track Proposals for Young Scientist scheme sponsored by Department of Science and Technology, Govt. of India (Award no. SR/FT/L-32/2004). Title of the project: ‘Antioxidant properties of Olive oil: Possible role in preventing environmental immunotoxicity and associated oxidative stress’. Total amount- Rs 10.02 lacs (Completed) (Dec 2004 to Dec 2007)
• UGC sponsored Major Project. Title of the project: Seaweeds inhabiting South Indian coastal area: Possible drugs for the treatment of neurodegenerative disorders. Total amount: Rs. 11.34 lacs (On going) (2009 to 2012)
• Ad-hoc project sponsored by ICMR, New Delhi. Title of the project: Gelidiella acerosa: Seaweed inhabiting gulf of mannar: Assessment of the possible suppression of dioxin mediated Immunotoxicity. Total amount: Rs 8.619 lacs (Principally selected)

Completed one students project sanctioned by TNSCT, Tamil Nadu on “Scavenging capacities of mangrove plants/seaweed extracts against free radicals- In vitro evaluation” ( Dec 2006 – April 2007)

Fellowship

• Junior research Fellowship by Tamil Nadu Government (TN-JRF)
• Junior Research Fellowship by Rameshwardasji Birla Smarak Kosh, Mumbai , India.
• Senior Research Fellowship by Council of Scientific and Industrial Research. (CSIR), New Delhi, India.

Achievements

• State Level Educational Testing (SLET) for Lectureship conducted by Government of Tamil Nadu, India.
• National Eligibility Test (NET) for Professor/Assistant Professor conducted by Agricultural Scientist Recruitment Board (ASRB), New Delhi, India

• Life Member of The Indian Science Congress Association, Kolkatta
• Life Member of Society of Biological Chemists, Bangalore

Other relevant information

Conferences/Seminar/Symposium

• Studies on the protective effect of Premna tomentosa on acetaminophen induced toxicity- Presented at “Women in Science conference” held at Tuberculosis Research Centre, Chetpet, Chennai, April 7 1998.
• Evaluation of anti-inflammatory potential of Premna tomentosa (L.Verbanacae) extract in rats - Presented at “National Symposium on Phytomedicine and Phytopharmacology” held at Department of Microbiology, Bangalore University, 29-30, November 2006.
• Biotechnological applications of Indian drug heritage: protective role of silymarin against oxidative stress - Presented at “XXX Indian Social Science Congress” held at Alagappa University, 27-31, December 2006.
• Herbal drug development: protective effect of silymarin against environmental contaminants - Presented at “XXX Indian Social Science Congress” held at Alagappa University, 27-31, December 2006.
• Exploration of ocean for development of biotechnological/pharmaceutical products: drug for neurological disorders from seaweeds - Presented at “XXX Indian Social Science Congress” held at Alagappa University, 27-31, December 2006.
• Cholinesterase inhibitors from seaweeds inhabiting South Indian coastal area (Hare Island, Gulf of Mannar Marine Biosphere Reserve) - Presented at International Conference on “ Biotechnological Approaches in Bioresource Management (ICBABM – 07)” held at Bharathidasan University, 23-26, January 2007.
• Protective effect of silymarin on Benzo(a)pyrene induced damages in human polymorphonuclear cells – Presented at “77 th Annual Meeting of Society of Biological Chemists” held at Indian Institute of Technology Madras, 18-20, December 2008.
• Protective effect of Olive oil and its constituents (Hydroxy tyrosol and Tyrosol) on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced damages in human peripheral blood mononuclear cells – Presented at “1 st World Congress on Cancer” (WCC-2009) held at Institute for Holistic Medical Sciences, 12-14, January 2009.
• Olive oil and its phenolics protects the human peripheral blood mononuclear cells against dioxin induced oxidative stress – Presented at International Colloquium on “Emerging Biotechnologies in Agriculture, Animal Health and Productivity” (ICEB’09) held at Alagappa University, 22-26, February 2009.
• In vitro evaluation of antioxidative property of Rhizophora mucronata inhabiting South Indian coastal area (Vellar Estuary)– Presented at International Colloquium on “Emerging Biotechnologies in Agriculture, Animal Health and Productivity” (ICEB’09) held at Alagappa University, 22-26, February 2009
• Antibacterial activity of Eugenol against Escherichia coli & Salmonella enterica Serovartyphi.– Presented at International Colloquium on “Emerging Biotechnologies in Agriculture, Animal Health and Productivity” (ICEB’09) held at Alagappa University, 22-26, February 2009.
• Silymarin inhibits B(a)P induced toxicity by modulating glutathione related enzymes and inhibiting CYP1A1 in human PBMC – Presented at International Colloquium on “Emerging Biotechnologies in Agriculture, Animal Health and Productivity” (ICEB’09) held at Alagappa University, 22-26, February 2009.
• Modulation of glutathione related enzymes as a protective mechanism of silymarin against BaP induced apoptosis and cytotoxicity in PBMC-An In vitro study – Presented at “National Seminar on Frontiers in Biotechnology” [NFSB-2009] held at Bharathiar University, 22-24, July 2009.
• Bactericidal activity and mode of action of Eugenol on Salmonella typhi – Presented at National Symposium on “Antimicrobial resistance and drug discovery” (II Louis Pasteur Momorial Symposium 2009) held at Dr.N.G. P. Arts and Science College, 9-10, September 2009.

Conferences/Seminars/Workshops/Symposia organized

• Organizing committee member for the National Seminar on Biotechnology of Transgenesis: Scientific Progress and Social Issues, Alagappa University , Karaikudi July 28 and 29, 2003.
• Executive Member, Organizing Secretary for the International Workshop cum Seminar on “Advances in Modern Biotechnology & Molecular Techniques in Veterinary parasitology: Diagnosis, Chemotherapy and Control”, March 17- 21, 2008 organized by School of Biotechnology , Alagappa University , Karaikudi.

 Editorial Board Member in International Journal

Nominated as Editorial Board Member for the journal African Journal of Food Science, published by Academic Press, Nairobi .

Reviewer to International Journals

• Pharmacology Biochemistry and Behaviour (Elsevier publishers)
• Phytotherapy Research (Elsevier publishers)
• BMC Complementary and Alternative Medicine (Biomed central, UK )
• International Journal of Food Science and Technology (Wiley-Blackwell)
• Invest.Clinica (Publication of the Universidad del Zulia , Venezuela )
• Medical Principles and Practice ( Karger , Switzerland )
• African Journal of Pharmacy and Pharmacology (Academic Journals, Nairobi )
• African Journal of Plant Science (Academic Journals, Nairobi )
• African Journal of Biochemistry Research (Academic Journals, Nairobi )
• Journal of Medicinal Plants Research (Academic Journals, Nairobi )
• Research in Complementary medicine ( Karger Press , Germany )
• Journal of Ecology and Natural Environment
• Biological Trace Element Research (Springer)