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Indian 05.03.1966 Assistant Professor Department of Biotechnology Alagappa University Karaikudi 630 003 Tamil Nadu INDIA + 91 4565 225215 + 91 4565 225202 aveeraravi@rediffmail.com

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Recent Publications:

Syed Musthafa. K., A. Veera Ravi, A. Annapoorani, ISV. Packiavathy and S. Karutha Pandian (2010), Evaluation of antiquorum sensing activity of edible plants and fruits through inhibition of AHL system in Chromobacterium violaceum and Pseudomonas aeruginosa.  Chemotherapy. 56 (4): 333-339.

 Syed Musthafa. K., A. Veera Ravi, A. Annapoorani, R. Jayakumararaj and S. Karutha Pandian (2010), Cross species signal transfer mediated induction of antibiotic production in Actinomycetes against Staphylococcus aureus, Journal of Pharmacy Research. 3 (2), 397-400.

Ramya, S, T. Palin Sathya Sudha, K.N. Sundandirakarthi, P.Vanitha, T. Nagajothi, A. Veera Ravi and R. Jayakumarram, (2010), Effect of methanol extracts of Andragraphis paniculata (Burmf) Nees on larvae of Helicoverpa armigera (Hubner). Journal of Pharmacy Research. (In Press).

RESEARCH INTREST:
SCREENING AND CHARACTERIZATION OF ANTIPATHOGENIC / ANTIMICROBIAL COMPOUNDS FROM NATURAL RESOURCES.
Antipathogenic compound:
Bacterial cell-to-cell communication known as quorum sensing (QS) depends on the production, diffusion and recognition of small signal molecules called autoinducer. Both Gram positive and Gram negative bacterial pathogens employ this autoinducer molecule to coordinate their virulence gene expressions during infection in higher organisms. The most intensively studied autoinducer molecule in Gram positive and Gram negative bacteria are pheromones and N-acylhomoserine lactone (AHL), respectively. Therefore, the anti-QS approach i.e., interfering with autoinducer activity could be used to prevent bacterial pathogenicity. Compounds with such attenuation abilities are termed as antipathogenic or anti quorum sensing compounds. We are currently working on screening and characterization of antipathogenic compounds from marine resources like sponges, sea weeds, sea grasses, mangroves and their associated bacteria and also from terrestrial resource such as medicinal plants, spices, etc.

Antibacterial compound:
With the discovery of antimicrobial agents, there is a remarkable progress in the prevention and control of infectious diseases. However, due to the development of antibiotic resistance, the infectious diseases are still remains a leading cause of global burden with high morbidity and mortality, which urges the need to find out new classes of novel antimicrobial compound to combat infectious diseases. The marine microorganisms have been largely unexplored source for its bioactive potential including its antimicrobial property. Therefore, we are also concentrating on the screening and characterization of antimicrobial compound from marine organisms to fulfill the need of preventing emerging bacterial infection.